126.1-Online: A Prescription for Therapeutic Drug Monitoring, 2nd Edition


Contact Hours (Points): 10

Therapeutic Drug Monitoring is a multidisciplinary approach to dosing a patient to determine the optimum drug effects and to minimize drug toxicity. This purpose of this course is to help the laboratorian understand their role in this process. The course covers the basic principles of

pharmacokinetics and how it relates to therapeutic drug monitoring. The commonly monitored drugs in many drug classes are discussed in relation to function, pharmacokinetics, therapeutic drug monitoring, and toxicity. Finally, this course reviews the various pre-analytical problems and analytical methodologies used in clinical laboratories performing therapeutic drug monitoring. The goal is to provide basic information on various drugs, methodologies for monitoring these drugs, and their therapeutic use, so medical professionals may fully understand the importance of the clinical assays and the possible impact on their patients.

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A Prescription for Therapeutic Drug Monitoring, 2nd Edition

Self-Study 126.1 – Basic Level

Contact Hours (Points): 10

Originally written by Pegi Emmett MA, MT(ASCP).

Revised by Matthew Schoell, PhD, MLS(ASCP)CM and Karen Krzisnik Apolloni, MSA, MLS(ASCP)CM

Published 2005, Revised 2015.

Online – 126.1: Course Taken Online: $100.00 BUY NOW

IMPORTANT: This online course is accessible using the following:

Desktop or Laptop Computer – Download the latest Adobe Reader program.

Kindle Fire – No additional App download is necessary.

Apple iPad (all versions) / Nook / Kindle – Recommend purchase of a PDF Reader App, such as GoodReader, Cloudreaders, or Stanza by Amazon. Once downloaded, launch this App to access the course online site in order to logon to and view your course.

Here’s what satisfied customers have to say~

“Enjoyed this course and it really helped my understanding of Therapeutic Drug Monitoring.”
~Robyn J.

“An extremely valuable course as both a refresher and teaching aid.“
~Jennifer H.

“Extremely detailed and informative.“
~Debbie O.



Introduction; Definition of Therapeutic Drug Monitoring; Uses for Therapeutic Drug Monitoring;Therapeutic Ranges

Pharmacokinetics; Distribution; Metabolism; Dosing; Generic vs. Brand Name; Summary of Pharmacokinetics


Antiepileptic Drugs; Carbamazepine; Clonazepam; Ethosuximide; Felbamate; Gabapentin; Lamotrigine; Oxcarbazepine; Phenobarbital; Phenytoin; Fosphenytoin; Primidone; Topiramate; Valproic Acid

Antiepileptic Drugs Case Histories; Case History #1; Case History #2

Antimicrobial; Aminoglycosides; Chloramphenicol; Flucytosine; Ketoconazole; Sulfamethoxazole; Vancomycin

Antimicrobial Case Histories; Case History #3; Case History #4

Antiarrhythmics; Amioderone; Digoxin; Digitoxin; Disopyramide; Flecainide; Lidocaine; Mexiletine; Procainamide; Propafenone; Propranolol; Quinidine; Tocainide; Verapamil

Antiarrhythmics Case History; Case History #5

Analgesics; Acetaminophen; Diflunisal; Fenoprofen; Ibuprofen; Meperidine; Naproxen; Propoxyphene; Salicylates; Tramadol

Analgesics Case History; Case History #6

Antidepressants; Alprazolam; Bupropion; Fluoxetine; Lithium; Sertraline; Trazadone

Tricyclic Antidepressants; Amitriptyline; Clomipramine; Desipramine; Doxepin; Imipramine; Nortriptyline; Protriptyline

Tetracyclic Antidepressants; Amoxapine; Maprotiline

Tetracyclic Antidepressant Case History; Case History #7

Theophylline and Caffeine; Theophylline; Caffeine

Theophylline and Caffeine Case History; Case History #8

Immunosuppressants; Cyclosporine; Mycophenolate; Sirolimus; Tacrolimus

Immunosuppressant Case History; Case History #9

Antineoplastics; Methotrexate;

Antineoplastics Case History; Case History #10


Spectrophotometric Methods

Immunoassay Methods; Enzyme Multiplied Immunoassay Technique (EMIT); Fluorescence Polarization Immunoassay (FPIA); Cloned Enzyme Donor Immunoassay (CEDIA); Radioimmunoassay (RIA); Chemiluminescence

Chromatography Methods; High Performance Liquid Chromatography (HPLC); Gas Chromatography

Issues Affecting Drug Analysis; Drug interactions; Protein binding; Preanalytical Factors; Analytical Factors; Cross-reactivities