CACMLE Hemostasis Courses

155-Online: Basic Hemostasis: Principles and Applications

$100.00

Contact Hours (Points): 10

This self-study course in hemostasis focuses on the laboratory diagnosis of coagulation disorders. Particular emphasis will be placed on the interpretation and correct performance of common laboratory procedures used to assess coagulation status. It is divided into 3 major parts: 1-Normal Hemostasis; 2-Vascular and Platelet Disorders; 3-Hereditary and Acquired Bleeding and Thrombotic Disorders. Visual aids in the form of diagrams and charts are also included. Case histories will be utilized to illustrate various disorders.

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Product Description

Basic Hemostasis: Principles and Applications

Self-Study 155 – Basic to Intermediate Level

Contact Hours (Points): 10

Written by Michael Sanfelippo, MS

Published 2010. Reviewed 2015.

Online – 155: Course Taken Online: $100.00 BUY NOW

IMPORTANT: This online course is accessible using the following:

Desktop or Laptop Computer – Download the latest Adobe Reader program.

Kindle Fire – No additional App download is necessary.

Apple iPad (all versions) / Nook / Kindle – Recommend purchase of a PDF Reader App, such as GoodReader, Cloudreaders, or Stanza by Amazon. Once downloaded, launch this App to access the course online site in order to logon to and view your course.

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“Very informative and thorough.”
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“This is an excellent course…concise and precise.“
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“Great course.“
~Carmen T.

TABLE of CONTENTS
PART 1 – NORMAL HEMOSTASIS
SECTION 1: THE VASCULAR COMPONENT OF HEMOSTASIS
Endothelial Cell Physiological Mechanisms Important in Hemostasis;Vasoconstriction/Dilatation; Local Control Mechanisms of Vasoconstriction; Neurogenic Mechanisms; Hormonal Influences; Endothelial Cell Surface Interactions; Coagulation Factor Synthesis; Prostaglandin Synthesis
SECTION 2: THE PLATELET COMPONENT OF HEMOSTASIS
Thrombopoiesis; Platelet Anatomy; Platelet Function in Hemostasis; Morphologic Changes with Platelet Adhesion and Aggregation; Platelet Adhesion; Aggregation/Release Reaction of Platelets; Laboratory Testing for Adhesion and Aggregation; Mechanism of Control of Platelet Plug Formation; Prostaglandin Interaction; Cyclic AMP
SECTION 3: THE PLASMA COAGULATION COMPONENT OF HEMOSTASIS
The Factor “Groups”; The Consumable Factors; The Vitamin K Dependent Group; The Contact Factor Groups: XI, XII, High Molecular Weight Kininogen and Prekallikrein; Intrinsic Pathway; Extrinsic Pathway; Common Pathway; Contact System and the Extrinsic Pathway; Regulators of Coagulation; The Fibrinolytic System; Other Actions of Factor XIIa;; The Complement System; Inflammation and Hemostasis; Conclusion
SECTION 4: BASIC COAGULATION SCREENING METHODS
Tests of the Vascular Component of Coagulation (The Bleeding Time Test; Screening Tests of Platelet Function; Platelet Counts; Dade Platelet Function Analyzer ; Test of Platelet Adhesion and Retention); Screening Tests for the Plasma Component of Hemostasis (The Prothrombin Time; The Activated Partial Thromboplastin Time (APTT); The Thrombin Time); General Considerations in Coagulation Testing
SECTION 5: QUALITY CONTROL IN THE COAGULATION LABORATORY
Procedural Quality Control; Reagent System Quality Control; Guidelines for Using Test System Quality Control Data; Population Range Control; Sample Calculation of a Reference Range for a Prothrombin Time Procedure
PART 2 – VASCULAR AND PLATELET DISORDERS
SECTION 1: VASCULAR DISORDERS
Inherited Vascular Disorders; Acquired Vascular Disorders; Vascular Abnormalities Attributed to Fragile Vessels; Vitamin C Deficiency (Scurvy); Acquired Vascular Disorders Secondary to Vascular Inflammation
SECTION 2: PLATELET DISORDERS
Inherited Qualitative Platelet Disorders; Glanzmann’s Thrombasthenia; Bernard-Soulier Syndrome; Storage Pool Disease; Abnormal Release Mechanism; Acquired Qualitative Platelet Disorders; Platelet Disorders Due to Chronic Disease States; Drug Interference; Inherited Quantitative Platelet Disorders; Wiskott-Aldrich Syndrome; May-Hegglin Anomaly; Acquired Quantitative Platelet Disorders; Radiation; Infection; Malnutrition; Splenomegaly; Acquired Platelet Coagulopathies of Unknown Etiology; Idiopathic Thrombocytopenic Purpura (ITP)
SECTION 3: LABORATORY METHODS FOR DIAGNOSIS OF BLEEDING DISORDERS
The Fibrin End Point Tests; Immunoassay; Chromogenic Assays; Platelet Aggregometry; In Vivo Testing; Patient History
PART 3 – Hereditary & ACQUIRED BLEEDING AND THROMBOTIC DISORDERS
SECTION 1: Hereditary DEFICIENCY OF CONTACT FACTORS
Hereditary Factor XII Deficiency; Case History; Hereditary Prekallikrein Deficiency (Fletcher Trait); Case History; Hereditary Deficiency in High Molecular Weight Kininogen (William or Fitzgerald Trait); Case History; Factor VIII Deficiency (Hemophilia A) and Factor IX Deficiency (Hemophilia B: Christmas Disease); Treatment of Hemophilia A; Treatment of Hemophilia B; Case Histories: Hemophilia A and Hemophilia B; Factor XI Deficiency (Hemophilia C, Rosenthal Syndrome); Case History; Factor X Deficiency; Case History; Factor V Deficiency (Parahemophilia); Case History; Factor VII Deficiency; Case History; Factor II Deficiency; Case History; Fibrinogen; Case History: Dysfibrinogenemia; Factor XIII Deficiency; Case History; Bleeding Disorders in the Vascular Phase; von Willebrand’s Disease; Platelet type von Willebrand’s Disease (pseudo von Willebrand’s Disease); Signs and Symptoms; Diagnosis ; Treatment
SECTION 2: ACQUIRED BLEEDING DISORDERS
Disseminated Intravascular Coagulation (DIC); Laboratory Diagnosis of DIC; Laboratory Tests for Activation of the Coagulation Pathway; Case Histories: DIC; Case 1; Case 2; Case 3; Liver Disease; Case History; Vitamin K Deficiency; Case History; Drug-Induced Platelet Dysfunction; Non-Steroidal Anti-Inflammatory (NSAI); Antibiotics; Plasma Volume Expanders; Tricyclic Antidepressives; Ethyl Alcohol; Caffeine; Dipyridamole; Theophylline and Aminophylline; Glycerol Quaiocolate; Case Histories: Drug-Induced Platelet Dysfunction; Case 1; Case 2; Thrombocytopenia; Case History; Thrombotic Thrombocytopenic Purpura (TTP); Case History
SECTION 3: ACQUIRED COAGULATION FACTOR DISORDERS
Acquired Coagulation Factor Disorders Due to Liver Disease; Laboratory Testing; Acquired Anticoagulants; The Lupus Anticoagulant; Laboratory Identification of the Lupus Anticoagulant; The APTT; Dilute Russell’s Viper Venom Time (DRVVT); Tissue Thromboplastin Inhibition Test (TTI); Hexagonal Phase Assay; Platelet Neutralization Test; Treatment of Lupus Anticoagulant; Factor VIII Inhibitor; Laboratory Identification of Factor VIII Inhibitor; Case History; Spontaneous Inhibitor to Factor V; Case History; Spontaneous Inhibitor to Thrombin; Case History
SECTION 4: ANTIGOAGULANT DRUGS
Unfractionated Heparin; Low Molecular Weight Heparin; Fondaparinux; Warfarin; Hirudan; Argatroban; Platelet Inhibitors; Aspirin; Clopidogrel; Abciximab (ReoPro); Dipyridamole (Persantine)
SECTION 5: THROMBOTIC DISEASE DUE TO DEFICIENCY OF REGULATOR PROTEINS
Antithrombin; Protein C and S System; Protein C; Protein S

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