Normal Hemostasis – Section 1 of “Basic Hemostasis: Principles and Applications”
Self-Study 157 – Basic to Intermediate Level
Contact Hours (Points): 3
Written by Michael Sanfelippo, MS
Published 2010. Reviewed 2015.
Online – 157: Course Taken Online: $36.00 BUY NOW
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TABLE of CONTENTS
PART 1 – NORMAL HEMOSTASIS
SECTION 1: THE VASCULAR COMPONENT OF HEMOSTASIS
Endothelial Cell Physiological Mechanisms Important in Hemostasis;Vasoconstriction/Dilatation; Local Control Mechanisms of Vasoconstriction; Neurogenic Mechanisms; Hormonal Influences; Endothelial Cell Surface Interactions; Coagulation Factor Synthesis; Prostaglandin Synthesis
SECTION 2: THE PLATELET COMPONENT OF HEMOSTASIS
Thrombopoiesis; Platelet Anatomy; Platelet Function in Hemostasis; Morphologic Changes with Platelet Adhesion and Aggregation; Platelet Adhesion; Aggregation/Release Reaction of Platelets; Laboratory Testing for Adhesion and Aggregation; Mechanism of Control of Platelet Plug Formation; Prostaglandin Interaction; Cyclic AMP
SECTION 3: THE PLASMA COAGULATION COMPONENT OF HEMOSTASIS
The Factor “Groups”; The Consumable Factors; The Vitamin K Dependent Group; The Contact Factor Groups: XI, XII, High Molecular Weight Kininogen and Prekallikrein; Intrinsic Pathway; Extrinsic Pathway; Common Pathway; Contact System and the Extrinsic Pathway; Regulators of Coagulation; The Fibrinolytic System; Other Actions of Factor XIIa;; The Complement System; Inflammation and Hemostasis; Conclusion
SECTION 4: BASIC COAGULATION SCREENING METHODS
Tests of the Vascular Component of Coagulation (The Bleeding Time Test; Screening Tests of Platelet Function; Platelet Counts; Dade Platelet Function Analyzer ; Test of Platelet Adhesion and Retention); Screening Tests for the Plasma Component of Hemostasis (The Prothrombin Time; The Activated Partial Thromboplastin Time (APTT); The Thrombin Time); General Considerations in Coagulation Testing
SECTION 5: QUALITY CONTROL IN THE COAGULATION LABORATORY
Procedural Quality Control; Reagent System Quality Control; Guidelines for Using Test System Quality Control Data; Population Range Control; Sample Calculation of a Reference Range for a Prothrombin Time Procedure