Lipids, Homocysteine, & Fibrinogen and Coronary Heart Disease
Self-Study 253 – Basic Level
Contact Hours (Points): 1.0
Written by David Plaut and Deena Davis, MLS
According the the Cleveland Clinic website article titled, “Blood Tests to Determine Risk of Coronary Artery Disease“,
Total Cholesterol (TC) is “directly linked to risk of heart and blood vessel disease.” High Density Lipoprotein (HDL) “Good cholesterol” in “high levels linked to a reduced risk of heart and blood vessel disease. The higher your HDL level, the better.” Low Density Lipoprotein (LDL) “Bad cholesterol” in “high levels are linked to an increased risk of heart and blood vessel disease, including coronary artery disease, heart attack and death. Reducing LDL levels is a major treatment target for cholesterol-lowering medications.” Apolipoprotein A1 (Apo A1) is defined as “the major protein of HDL. Low levels of Apo A1 is associated with increased risk of early cardiovascular disease, and may be seen more often in patients with a high-fat diet, inactivity and central obesity.” Apolipoprotein B (ApoB) is defined as “a major protein found in cholesterol particles. New research suggests ApoB may be a better overall marker of risk than LDL alone.” Lipoprotein a (Lp(a)) is defined as a “non-traditional” blood protein associated with higher risk of heart attack and stroke.” Triglycerides (TG) is “elevated in obese or diabetic patients. Level increases from eating simple sugars or drinking alcohol. Associated with heart and blood vessel disease.” LDL-associated PLA2 (PLAC) “… measures the level of lipoprotein associated-phospholipase A2 (Lp-PLA2), an enzyme associated with inflammation, stroke and heart attack risk. However, elevated levels also may be due to non-arterial causes.” Fibrinogen is defined as “A protein found in the blood. Encourages blood clotting, but high levels are linked to an increased risk for heart attack and vascular disease.”[http://my.clevelandclinic.org/heart/diagnostics-testing/laboratory-tests/blood-tests-to-determine-risk-of-coronary-artery-disease.aspx]
According the the WebMD website article titled, “Heart Disease and Homocysteine“,
“Homocysteine is a common amino acid (one of the building blocks that make up proteins) found in the blood and is acquired mostly from eating meat. High levels of homocysteine are related to the early development of heart and blood vessel disease. In fact, it is considered an independent risk factor for heart disease.“[http://www.webmd.com/heart-disease/guide/homocysteine-risk]
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